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investigated the therapeutic mechanisms of MSCs and found that human adipose-derived mesenchymal stem cells (hAd-MSCs) had postradiation healing effects, including anti-inflammation, neovascularization and maintenance of epithelium homeostasis, as indicated by the elevated serum IL-10, upregulation of vascular endothelial growth factor, basic fibroblast growth factor and epidermal growth factor in irradiated intestine, mobilization of CD31-positive hematopoietic stem cells or hematopoietic progenitor cells, and the prolonged presence of Bmi1-positive cells within crypts

This hypothesis is a good explanation for the phenomenon that AAS is significantly more prevalent in developed countries in comparison with underdeveloped countries

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Cases 3 and 4 illustrate the approach to hypokalemia of renal and extrarenal origin and the response to therapy In Case 3, a 32-year-old man was referred to the nephrology clinic because of persistent hypokalemia