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doi: 10.1111/j.1365-3040.2007.01764.x 22 DevereuxR

Second, it is able to induce the combination of ,-unsaturated ketones and GSH through the nucleophilic addition reaction, depleting GSH and reducing the amount of GSH available to combine with chemotherapeutic agents, thus producing an overall GST-inhibitory effect by sensitizing a cell to chemotherapeutic agents