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GPX3 exhibits its activity within the cytoplasmic lysosomes and plasma membranes of mammalian cells located in various organs such as the kidney, heart, lungs, liver, brain, adipose tissue, mammary glands and gastrointestinal tract (25)

The ANLS hypothesis draws heavily on data from techniques that measure metabolites and oxygen directly in the brain parenchyma (e.g., microsensors, microdialysis), emphasizing the rapid dynamics of a local lactate and oxygen pool (Hu and Wilson, 1997

If the patient is pink and has never had a cyanotic spell, elective surgery is usually performed in the first few months of life by closing the VSD and relieving the RVOTO