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Miele E, et al

Elucidating how Nrf2 preferentially upregulates target genes to avert various forms of oxidative cell death could facilitate the design of new treatments and preventative strategies for iron-associated illnesses

Electrophysiology Neurons were constantly perfused at 3 ml min 1 with heated (3032 C), gassed (95% O 2 , 5% CO 2 ) artificial cerebrospinal fluid (pH 7.4, 300305 mOsm) containing (in mM): 119 NaCl, 2.5 KCl, 1.3 MgCl 2 , 2.5 CaCl 2 , 26 NaHCO 3 , 1.3 NaH 2 PO 4 , 20 D-glucose and 0.5 sodium ascorbate