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4 Synthetic cathinones Synthetic cathinones, colloquially known as bath salts, exhibit profound neurotoxic effects by affecting monoaminergic neurotransmission, oxidative stress, excitotoxicity, and neuroinflammation

When hearts are stressed by disease, energy substrates, called purines, wash out of the cell and the total pool of cellular energy becomes severely depleted

Peripheral NP encompasses conditions such as painful diabetic neuropathy, postherpetic neuralgia, nerve entrapment syndromes, and neurological conditions due to genetic, metabolic, and toxic factors including some antitumoral and cancer chemotherapy treatments like cisplatin as well as immune-mediated neuropathies

In contrast, TML in erylysate ( Figure 2B ) remained at its initial level until 24 h pi and peaked at d 14 pi