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In a multivariate analysis, upregulation of LRP8 was the strongest risk factor for CNS relapse (OR 5.2, p=0.004), demonstrating greater impact than classical risk factors of CNS disease (age, MRD status and white blood cell counts (WBC)) ( Figure 5G )

Unlike continuous GH administration, GHRP-6 maintains physiological feedback controlsas GH and IGF-1 levels rise, endogenous somatostatin increases to prevent excessive elevation, keeping GH pulses within normal physiologic ranges [5]

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