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High-dose vitamin E supplements may interfere with blood clotting, cause hemorrhages, and lead to hemorrhagic stroke (22)

Like most treatments, vitamin B12 injections carry warnings that patients should be aware of, including: Hereditary Optic Nerve Atrophy: People with early Lebers disease (a hereditary form of optic nerve atrophy) should not receive cyanocobalamin injections, as rapid and severe vision loss has occurred

Brachs S, Polack J, Brachs M, Jahn-hofmann K, Elvert R, Pfenninger A, Brenz F, Margerie D, Mai K, Spranger J, Kannt A (2018) Genetic Nicotinamide N -Methyltransferase (Nnmt) deficiency in male mice improves insulin sensitivity in diet-induced obesity but does not affect glucose tolerance