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Among over 20 distinct RCD modalities reported, ferroptosis, described as a ROS-dependent non-apoptotic iron-driven cell death [496], has attracted considerable attention as a potential therapeutic target in cancer [497]

Interim analysis of the EAGLE trial: an open-label study to assess the long-term safety and tolerability of bardoxolone methyl in patients with alport syndrome: PO1300

ROS are reactive forms of oxygen which include superoxide anion radical, hydrogen peroxide, singlet oxygen and hydroxyl radical, they are usually produced during normal metabolism of oxygen inside the mitochondria [116]

10.1016/j.redox.2020.101509 13 BuenoM.LaiY