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In addition to these established topical options, emerging evidence suggests that topical amitriptyline may provide clinically meaningful pain relief with acceptable tolerability in BMS, whereas topical doxepin has demonstrated analgesic efficacy in head-and-neck mucositis pain in randomized trials 19,20

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EAAC1/EAAT3 supplies neurons with the rate-limiting precursor for GSH synthesis, directly influencing their redox homeostasis ( Glucose metabolism, GSH synthesis and glutamatergic homeostasis are closely associated processes and share extracellular and intracellular regulatory mechanisms

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