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While many of these diseases were once localized to specific geographical regions, recent expansion of the causative agents (ticks, mosquitos, etc.) has resulted in an increased incidence of diseases in areas once considered low-risk

Y.A.M.: data curation, writingoriginal draft preparation

Esculin can inhibit oxidative stress in liver injury, as esculin (10-40 mg/kg) can activate the Nrf2 signaling pathway to increase HO-1 expression levels and decrease the MDA content in lipopolysaccharide (LPS)/D-galactosamine-induced acute liver injury mice (61)

(1) Direct antioxidant activity of NAC as an oxygen radical scavenger For a compound to act as an antioxidant in a biological matrix, its reaction rate with oxidants must be higher than that of endogenous antioxidants and much higher than that of the substrates present [37]