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Our results indicate that monitoring the spatial distribution of [1- 13 C]6PG production from hyperpolarized -[1- 13 C]gluconolactone serves to demarcate tumor from surrounding normal-appearing contralateral brain, thereby highlighting the ability of hyperpolarized -[1- 13 C]gluconolactone to provide a readout of tumor burden in vivo

Depleted levels of glutathione are recognised to result in susceptibility to cellular deterioration, as a result of multiple circumstances, including oxidative stress, free radical exposure, infections, and toxins

Clarifying regulatory mechanisms and targeting biomarkers of CSCs is currently the mainstream idea

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