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found that mice lacking the GLAST gene developed spontaneous retinal ganglion cell (RGC) reduction and optic nerve degenerative changes, suggesting that reduced GLAST expression leading to glutamate excitotoxicity in the retina may be a potential pathogenetic mechanism for glaucoma (69)

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The inherently elevated metabolic activity in the liver and breast muscle of broilers means that these tissues are potentially more susceptible to oxygen radical production, and thus an increase in oxidative damage

Moreover, some peaks that appeared increased in the samples exposed to the nanoformulations (Fig