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Replication studies for genetic variants in these and in other glutathione-related genes are necessary to clarify the role of glutathione in Hg toxicity

Mutat Res Rev Mutat Res

Recent experimental work consistent with this framework includes studies of CYP2E1-mediated oxidative stress in alcohol-related liver injury and of stage-dependent oxidative responses in repeated toxic liver injury ( That said, it is tempting, but not yet defensible, to infer a causal link between glutathione administration, dampening of inflammation, and MELD-3 improvement in the subgroup with CRP reduction (Figure 8)

3% to 5%: These concentrations are often found in stronger treatments used for addressing more severe pigmentation issues like melasma and stubborn dark spots