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Through cholesterol depletion, the DOX@MINP-TRF/ChO drug-loaded nanosystem downregulates the expression of PD-1 and PD-L1, significantly increasing the proportion of infiltrating CD8 + T cells in GL261 glioma-bearing mice ( Immune checkpoint inhibitors (such as PD-1/PD-L1 inhibitors) have limited efficacy in GBM treatment, primarily because of the highly suppressive TIME

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Such disruption could lead to reduced physical and cognitive performance [72,73,74], hallmarks of this syndrome

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