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While the activity of NHR-49 is regulated at multiple levels including cofactor interactions, heterodimerization with other nuclear receptors, and isoform-specific subcellular localization 23,42,45,46,47,48 , nuclear hormone receptors are classically defined as ligand-regulated transcription factors 49,50,51,52,53

Depletion of the persulfide-generating enzyme sulfide:quinone reductase (SQR) (Extended Data Fig