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Finally, continuous evaluation of the necessity of propofol and exploring opportunities to transition to alternative sedative agents or non-pharmacological interventions when appropriate should always be considered in all cases

Symptoms of severe vitamin B12 deficiency can include visual disturbances, severe joint pain, paresthesia (tingling in the hands and feet), memory problems, depression, anxiety, poor muscle function, ataxia (impaired balance and coordination), changes in reflexes and even infertility

1 This most commonly occurs at the first metatarsophalangeal joint, but also occurs at other joints, e.g

Because it is essentially water without sufficient solute, direct intravenous administration can cause red blood cell lysis (hemolysis) due to its hypotonic nature