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Initial evidence suggesting a role for the melatonin receptor in behaviors associated with depression stemmed from the antidepressant-like effects of melatonin and its agonists in rodent studies involving learned helplessness

10.3389/fbioe.2021.807883 294 ZehraU.Robson-BrownK.AdamsM

In vivo confocal microscopy of all corneal layers 6 months post-operatively indicated an intact epithelial cell mosaic, preserved sub-basal nerves, and normal anterior and posterior stroma and endothelium in both groups (Fig

These effects were dose-dependent, with the 54 mg dose (substantially higher than standard protocols) showing increased GI-related events