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Recent studies have also investigated clinical implications of GS, including its association with metabolic associated steatotic liver disease, cardiovascular disease, mental health and mortality risk, highlighting the complex interplay between genetic factors, bilirubin metabolism, and clinical outcomes

Data synthesis focused on mechanistic evidence describing how toxicants particularly microplastics, heavy metals, and endocrine-disrupting chemicals interfere with physiological and biochemical pathways, leading to outcomes such as renal dysfunction, neurological impairment, respiratory disorders, and endocrine disruption

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Figure 6 ATF4 May Regulate Asn Metabolism by Promoting ASNS Expression in GC To explore the clinical correlation between ATF4 and ASNS expressions, the level of ASNS was also evaluated in the same batch of tissue array ( Figure 7A )