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386 This conclusion remains unchanged even when considering prior use of CDK4/6 inhibitors

The short answer is: yes, and often with synergistic benefits

Using a high-content phenotypic assay, researchers identified small molecules such as RH1115, which modulates autophagic flux by targeting proteins like Lamin A/C and LAMP1, promoting neuronal health and altering lysosome positioning for potential therapeutic benefit [140]