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The final results showed that these bonds confer a dual response of MMP-2 and ROS nanocarriers to exert specific drug release effects within RA joints, thereby promoting the drug concentrations of triptolide and curcumin in the lesion tissue (Fig

1 Their overlapping features include joint hypermobility, skin and vascular fragility, and generalized connective tissue friability 2 but the variability and clinical overlap can make the clinical diagnosis of a specific EDS subtype challenging