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Activated microglial cells produce and secrete AGE-albumin to induce RAGE expression in neurons and promote neuronal cell death, thereby contributing to neurodegenerative disorders 4,108

LC-MS/MS is the current gold standard due to its high sensitivity and specificity and its ability to quantify multiple compounds simultaneously, but its usage is limited by the need for specialized trained staff and by high efforts and costs

The mechanism is to promote the GSH levels and reduce MDA, lipid peroxidation, and mitochondrial reactive oxygen ROS ( 3.5 Hormones and novel regulatory factors The suppression of interferon regulatory factor 9 (IRF9) enhances the differentiation of osteoclasts, consequently hindering ferroptosis and potentially offering a new avenue for the treatment of osteoporosis ( in vivo and in vitro ( 3.6 Advanced delivery systems targeting ferroptotic hubs Although the research on natural ingredients combined with advanced delivery systems is limited, it is still an innovation and a future research direction