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Additional heterogeneity arises from diverse interventions (different formulations, routes, dosages, durations) and inconsistent comparators, compounded by non-uniform outcome definitions and diagnostic criteria for liver injury

Clin Infect Dis 49(11):17031710 Leiding JW, Holland SM (2012 [updated 2016]) chronic granulomatous disease

Dann, A

It emerged from a body of protein-engineering work in the late 1980s and early 1990s much of it from the Australian laboratories associated with Francis, Ballard, and Wallace aimed at producing IGF analogs with reduced IGFBP affinity but preserved receptor activity, in order to study the relative contributions of binding-protein interaction versus receptor binding to biological potency