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Chitosan also increases the hydrophilicity of the nanoparticles, which contributes to the enhancement of the NP stability in the aqueous environment

A good example of this is given by flutamide, an antiandrogen used in the treatment of prostatic carcinoma, which undergoes substantial metabolism in vivo with hydrolysis of the amide bond liberating 3-trifluoromethyl-4-nitroaniline

Furthermore, understanding how this metabolites physiology level changes in connection to other aspects of clinical normalcy may be interesting (196)

Virus-shaped mesoporous silica nanostars to improve the transport of drugs across the blood-brain barrier