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Description

While demonstrating biological plausibility and mechanisms, in vitro conditions poorly replicate complex in vivo environment

Navot et al., 1994)

MYC functions as a central regulator of glutamine metabolism in prostate cancer by repressing miR-23a/b, thereby relieving the inhibition of mitochondrial GLS and promoting glutaminolysis, particularly in androgen-independent PC-3 cells (36, 37)