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A previous study demonstrated that ischaemia/reperfusion injury (IRI)-induced immune cell infiltration of the cremaster muscle was mediated by ferroptosis, and Fer-1 directly inhibited leukocyte transmigration or created a milder proinflammatory microenvironment, which may have been caused by a decrease in DAMP release secondary to the decrease in ferroptosis 11, 60

Orthobiologic treatments like PRP and cell-based therapy are a safer, less invasive alternative to cortisone shots

Stable for months to years when frozen [13]

Functionalization with targeting ligands further enhances uptake by neurons or glia, enabling precise regional delivery