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Succinate and fumarate Inactivating mutations in TCA cycle enzymes fumarate hydratase (FH) and succinate dehydrogenase (SDH) are driver mutations in a subset of human cancers and they mediate epigenetic reprogramming

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A broader panel may reveal whether the problem involves low SAM production, elevated SAH, impaired remethylation, creatine demand, transsulfuration, mitochondrial energy or poor clearance.

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Acknowledgements This work was supported by the Intramural Research Program of the NIH/National Institute of Environmental Health Sciences 1Z01ES090079

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PubMed Central , Redox Biology , vol

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