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It has been established that several mechanisms may contribute to the dysfunction of HBV-specific T cells, such as continuously high viral load and high antigen levels, suppressive cytokines including interleukin-10 (IL-10) and transforming growth factor- (TGF- ), dendritic cells (DCs) and regulatory T (Treg) cells, which were able to result in a progressive loss of T-cell function and cause HBV-specific T cells to become exhausted 7, 8 (Figure 1)

Secondary metabolites are the most important antioxidant substances in plants and usually the active ingredients of herbal medicine, therefore, the biological mechanisms of plant adaptation to adversity stress are also the mechanisms of quality formation of herbal medicine

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