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Nonetheless, decreased L-tryptophan levels are correlated with indicators of impaired protein metabolism and IRS responses in MDD patients, including decreased serum zinc, transferrin, and high-density lipoprotein cholesterol (HDL-C) levels and elevated leukocyte counts and CD4 + /CD8 + T-cell ratios [68, 69]

Univariate ROC analysis revealed lower AUC for these specific metabolites in different groups

One cigarette was used for every 10 mL of the medium, and each cigarette provided 11 puffs