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A malfunctioning Hypothalamus-Pituitary-Adrenal or HPA axis can result in a poor TSH feedback loop

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A group of patients with very severe neuropathies showed impaired CoQ 10 synthesis, indicating the importance of CoQ 10 homeostasis in human health (Asencio et al., In individuals with primary CoQ 10 deficiency, early treatment with high-dose oral CoQ 10 supplementation improves the pathological phenotype, limits the progression of encephalopathy, and helps recover kidney damage (Montini et al., 2008)

Finch JL, Suarez EB, Husain K, Ferder L, Cardema MC, Glenn DJ, Gardner DG, Liapis H, Slatopolsky E (2011) The effect of combining an ACE inhibitor and a VDR activator on glomerulosclerosis, proteinuria and renal oxidative stress in uremic rats