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DAmora P, Silva IDCG, Tewari KS, Bristow RE, Cappuccini F, et al

AC, PC & YM: are responsible for biological and genetic tests/monitoring

378 On the basis of the increased activity of -gal in senescent cells, a new prodrug, SSK1, which can be specifically cleaved by lysosomal -gal into cytotoxic substances and induce the apoptosis of senescent cells, thereby eliminating senescent cells, was developed

The outward-open conformation of the dDAT substrate-free state is consistent with the behavior of other NSS members including LeuT whose substrate-free ion-bound conformation is also in the outward-open state 37,38