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A novel human -globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction

The results revealed that compared to OVA control, the AGE + OVA group displayed a significantly higher frequency of CD4 + tetramer-positive cells, which provides compelling evidence that AGEs exposure amplifies OVA-specific Th2 responses (Supplementary Fig

By introducing exogenous reduced glutathione, the body gains the necessary reducing equivalents to neutralize the superoxide radicals that are actively damaging the mitochondrial inner membrane