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One study compared the effects of high-dose duloxetine, pregabalin, and duloxetine with pregabalin combination therapy in 343 patients with a MNSI score 3 and who did not show improvement in pain with duloxetine or pregabalin monotherapy

J Biol Chem (2002) 277(13):11297305.10.1074/jbc.M100822200 67 RadtkeSHaanSJorissenAHermannsHMDiefenbachSSmyczekTet alThe Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression