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The combined administration of PQ with maneb or its closely related chemical, mancozeb, has also been applied to study the effects of PQ on the nigrostriatal dopamine system and was found to reproduce PD symptoms better than PQ alone (Thiruchelvam et al., 2000a,b)

Invasive: This temperature measurement takes place via a body orifice with comfort impairment for the patient (esophagus, urinary bladder, nasopharynx), directly in the body tissue (needle probes) or in the blood vessel system (e.g