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All intermediates and final products were characterized using 1 H NMR spectroscopy, 13 C NMR spectroscopy, and high-resolution mass spectrometry (Supplementary Figs

Gln solved in aqueous solution constructs the cyclized compound pyroglutamic acid (Figure 1), which is an uncommon amino acid associated with metabolism problems [1]

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Histamine is a chemical produced by the body to defend against allergens such as pollen, mold, and foods (KidsHealth, n.d.)