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Worth noting: 47% of pregnant or breastfeeding women ages 1950 are at risk for at least 1 vitamin deficiency, with Vitamins A, B6, B12, E, and C among the most common gaps

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The Caco-2 cells incubated with mitragynine at 0.1, 1, and 10 M for 72 h showed downregulation of mRNA and protein expression of the P-gp in a concentration-dependent manner ( Evidence of alteration of cellular barrier function by mitragynine in long-term exposure is concerning