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Relevance to tissue-repair research more broadly IGF-1 signaling intersects with the wider field of musculoskeletal repair research, where a range of peptides are studied for their proposed effects on connective tissue, tendon, and muscle

Moreover, adherence to the MD not only positively impacts clinical parameters such as weight, waist circumference, hepatic fat accumulation, insulin resistance, alanine transaminase levels, gamma-glutamyl transferase, total cholesterol and triglycerides, but also beneficially influences inflammatory biomarkers, including adhesion molecules and cytokines [129]

10.1038/npp.2016.31 [DOI] [PMC free article] [PubMed] [Google Scholar] Elkin ER, Bridges D, Loch-Caruso R, 2019