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Variations, especially in foods of plant origin, could be attributed to factors such as plant varieties and cultivars, growing conditions (e.g., season and climate), and agronomic practices (e.g., harvest time and postharvest handling)

Consistent with this function, it has been shown that APAP induces autophagy both in primary mouse hepatocytes and intact liver and therefore the pharmacological promotion of autophagy by rapamycin protects against APAP hepatotoxicity (Ni et al., 2012a, 2013)

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In the same way, if you use a certain drug for long enough, youve developed tolerance (or practiced techniques to make use safer)