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In the context of thalassemia, at least one study suggests vitamin E supplementation may help support the integrity of red blood cell membranes (Sutipornpalangkul 2012)

Sarafraz-Yazdi et al., 2010)

Abnormal enterocyte differentiation and increased enterocyte apoptosis due to the failure of the cells to maintain ionic balance and by increased production of interferon- (IFN) and TNF results in a reduction in the height of the villus and an increase in crypt depth [62]