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Antioxid Redox Signal 2021;35:71833 [DOI] [PMC free article] [PubMed] [Google Scholar] 13.Saito C, Lemasters JJ, Jaeschke H.c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

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In simple terms, oxidative stress occurs when there are too many reactive oxygen species (free radicals) and not enough antioxidants to neutralize them