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Drop back to the previous dose and attempt escalation again after an additional 2-4 weeks

Laurans L, Venteclef N, Haddad Y, et al

The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison