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Crystallization of full length nuclear receptors remains a formidable challenge, and currently, only two structures of nuclear receptors that include all functional domains have been solved by the Rastinejad group (HNF-4 homodimers (PDB: 4IQR) 34 and PPAR/RXR heterodimers 33 complexed with their DNA elements and coactivator peptides)

Int J Mol Sci 2020;21:1170

This result confirms excellent labeling accuracy and batch consistency, ensuring researchers receive the intended peptide amount without underfilling or discrepancies

Separately, several smaller studies published in the last few years have examined RDW as a marker of illness severity in specific conditions, including sleep-related breathing problems and certain infections, generally finding that higher RDW values track with more severe disease