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Selenium status, for instance, differs dramatically by geography: populations in low-selenium regions may benefit from targeted intake, whereas those in replete environments risk toxicity with supplementation (199)

When similar clinical studies are performed in humans, we will all have some baseline level of nutrients in our bodies simply because of the food we eat

Hamilton NA, Affleck G, Tennen H, Karlson C, Luxton D, Preacher KJ, Templin JL: Fibromyalgia: the role of sleep in affect and in negative event reactivity and recovery

For instance, Hevin promotes excitatory synapse formation by bridging neurxin 1 and neuroligin 1, whereas SPARC antagonizes this effect, thereby refining synaptic connections