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Association of prior treatment with anti-EGFR monoclonal antibodies with downregulation of circulating TRAIL and upregulation of EGFR and VEGF family ligands in metastatic colorectal cancer

Supporting this hypothesis, we observed that despite the more oxidised than expected cytosolic NADP redox state, it seems to be coupled with a remarkable robustness to perturbation by exogenous oxidants in both yeast and mammalian cells