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Weinreb, R.N., Kaufman, P.L

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We also reported decreased mitochondrial activity and disintegrated mitochondria, increased lipid droplets and glycogen granules, enlarged and annular autophagolysosomes, and increased cytotoxicity to oxidative stress 10

Increasing the stability of wild-type p53 can promote the expression of its transcriptional target gene CDKN1A (encoding p21 protein), which can increase the intracellular glutathione level, inhibit the accumulation of ROS, and negatively regulate ferroptosis of cancer cells