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FIGURE 1 3.2 Oxidative stress markers, H 2 S level and mtNOS activity in heart mitochondria in glutathione-treated old rats It was shown that in old rat heart mitochondria, the values of oxidative stress indicators such as generation rates of O 2 and H 2 O 2 as well as the content of the primary products of lipid peroxidation products (DC and MDA) were higher in heart mitochondria of old rats comparing to adult ones (Table 2) indicating aggravation of free radical processes with age

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Topical application must penetrate the skin barrier, and even the best formulations lose a significant portion of the active compound during that process