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In control mice, metastases were found in 3 out of 9 tumor-bearing mice, all of them being from tumors of the reproductive organs

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Proteomic analysis further demonstrated that hexokinase 2 (HK2), which catalyzes the first step of glycolysis by converting glucose to glucose-6-phosphate, was significantly downregulated at the protein level (Supplementary Fig

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During this time hyperarousal symptoms and avoident behavior become increasingly severe and disabling

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