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Ashwagandha has historically been used to treat a variety of conditions, including weakness, erectile dysfunction, performance anxiety in males, and decreased desire for sex in both sexes [171, 196, 197]

Paradoxically, in early ischemia, lactate overabundance fuels a pro-inflammatory M1-dominant milieu [153]

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Outliers were removed from control data after identification with ROUT Q = 0.5% (number of outliers removed: NAD + /NADH ratio n = 2, NADP + /NADPH ratio n = 11 and GSH/SSG ratio n = 6, no outliers were identified for individual metabolites)