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Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action As a copper chelator, GHK-Cu modulates over 4,000 human genes, upregulating those involved in tissue remodeling (e.g., collagen I, III) and downregulating pro-inflammatory pathways like NF-B

Side effects that are noted are usually mild and include momentary irritation at the injection site and fatigue

Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers