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This is caused by transient abnormalities in chemical levels within the brain

Upon recruitment to developing plaques, monocytes encounter many inflammatory stimuli such as damage associated molecule patterns (DAMP), oxLDL, and IFN that trigger inflammatory cascades after engagement with toll-like receptors (TLR), scavenger receptors and cytokine receptors, respectively

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To ensure that our findings are attributed to varying degrees of AD pathology and not external variables, we conducted correlation analyses between positive pixel density scoring and age, gender, post-mortem delay, and fixation time