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In humans, the levels of complement factors C3 and C4 have been associated with cardiometabolic risk factors such as obesity, insulin resistance, fat distribution, metabolic syndrome, and diabetes (Arias de la Rosa et al., 2020

However, some cancer cells can adapt to the glutamine unavailability by reprogramming metabolism, thus limiting the success of this therapeutic approach

FIGURE 1 Fundoscopy We demonstrated the specific damaging effect of L-NAME application

Its modular architecture also permits the incorporation of additional biologics, such as immunomodulatory cytokines or checkpoint inhibitory antibodies, suggesting broad adaptability for combination therapies in glioma management